GL-V9 also inactivated AMPK/MLC/ERM signaling axis of suspension-grown HCC cells (Fig. 5C and Supplementary Fig. S4G), and abolished the activating effects of GSK1016790A on AMPK/MLC/ERM axis (Fig. 5D and Supplementary Fig. S4H). This evidence concerns the gene PRKAA2 and hepatocellular carcinoma.