In MHCC-97H and HCC-LM3 cells, the regulation of TRPV4 by GSK1016790A or HC067047 had no effect on ATP production or glycolysis (Supplementary Fig. S2C), but it substantially altered the level of cytoskeleton-related protein MLC and ROCK1. This evidence concerns the gene TRPV4 and hepatocellular carcinoma.