We further evaluated the diagnostic sensitivity and specificity of both genes by ROC curves, and both genes had good diagnostic value in the experimental set (Fig. 7C,D): BTK (AUC = 0.909) and ITGAL (AUC = 0.937) in atherosclerosis; BTK(AUC = 0.840) and ITGAL(AUC = 0.873)in periodontitis. Here, BTK is linked to periodontitis.