The LN metastasis-positive patients had high nuclear grade (p = 0.02), lymphovascular invasion (p < 0.01), and vessel invasion (p < 0.01), bigger tumor size (p < 0.01), and reduced E-cadherin expression (p < 0.01) than the LN metastasis-negative patients, in univariate analysis (Table 2). Here, CDH1 is linked to neoplasm.