TFRC and hepatocellular carcinoma: It has shown that miR-148a [65], miR-107 [66], and miR-378g can downregulate TFR1 expression by binding to TFR1 3’UTR [67], affecting intracellular iron homeostasis and promoting the proliferation of hepatocarcinoma (HCC), colorectal cancer, and laryngeal cancer cells, respectively.