One study identified the role of miR-214 in inhibiting angiogenesis and promoting apoptosis in HCC by using a miRNAs mimetic and inhibitor transfection manner [103], while miR-214 is frequently downregulated in HCC, and the paracrine activation of hepatoma-derived growth factor (HDGF) promotes tumor angiogenesis. The gene discussed is HDGF; the disease is hepatocellular carcinoma.