Recent studies have reported that miR-539 can activate the stress-activated protein kinase/jun N-terminal kinases (SAPK/JNK) signaling pathway by targeting tumor necrosis factor (TNF) -α-induced protein 8 (TIPE) and reduce the expression of GPX4 to inhibit ferroptosis in colorectal cancer cells [49]. This evidence concerns the gene TNF and colorectal cancer.