The in vivo xenograft tumor growth with ALKBH5 KO cells stably re-expressing wild-type ALKBH5 was restored to that with NC cells, whereas the in vivo xenograft tumor growth with ALKBH5 KO cells stably re-expressing the K235R mutant was not restored to that with NC cells and was similar to that with ALKBH5 KO cells (Fig. 9e). Here, ALKBH5 is linked to neoplasm.