We also detected SARS-CoV-2 spike protein expression in lung macrophages in infected hamsters five days after infection and in circulating monocytes of vaccinated patients who had recovered from COVID-19, indicating that monocytes/macrophages may be a viral reservoir contributing to “long” COVID or “post-acute COVID-19 syndrome (PACS)”61,62. This evidence concerns the gene CHMP5 and COVID-19.