For example, in breast cancer, collagen I and collagen VI could induce the expression of CSCs markers, while collagen IV and vitronectin promote CSCs differentiation, leading to a decreased CD44+ /CD24- CSCs population.10 ECM compounds such as fibronectin and hyaluronic acid were also reported to promote the enrichment of CD44+ glioblastoma stem cells.11,12 Increasing investigations provide evidence that ECM composition dynamically regulates CSCs development and dormancy, which determines drug resistance and tumor relapse occurrence. This evidence concerns the gene VTN and breast cancer.