Collagen I and laminin were previously reported to induce epithelial-mesenchymal transition, a major cellular transformation from a differentiated state to a stem cell-like state, by activating focal adhesion kinase signaling.35–37 Additionally, several ECM components, such as collagen, laminin, and fibronectin, reportedly preserve cancer cell stemness by activating transcriptional programs that induce self-renewal. Here, FN1 is linked to cancer.