Evidence also indicates that AIRE interacts with the coactivator CREB-binding protein that regulates transcription factors, including NF-κΒ, STATs, and HIF-1α, which play vital roles in cancer stemness.51 Therefore, our findings highlight the crucial role of AIRE in cancer stemness and tumor formation, and points to a novel direction for future research. Here, HIF1A is linked to neoplasm.