Previous studies have suggested that dynamic ECM remodeling plays a crucial role in tumorigenesis and tumor progression.3 The diverse composition of ECM components, including fibrous proteins (collagen), glycoproteins (fibronectin and fibrinogen), and proteoglycans, also participates in tumor progression via multiple molecular mechanisms.4–6 However, the specific role of the ECM in remodeling tumor behavior remains controversial. This evidence concerns the gene FN1 and neoplasm.