NPC1 and nasopharyngeal carcinoma: Mutations in NPC1 can be found in ∼95% of NPC patients, although the gene’s product (the NPC1 protein) functions in late endosomes and lysosomes, where it transports unesterified cholesterol to the plasma membrane and to cellular organelles (Kwon et al, 2009; Vanier, 2010; Vance & Karten, 2014).