NFKB1 and Parkinson disease: A recent study suggests that the SARS-CoV-2-spike glycoprotein can activate microglia through the mediation of the ACE-2-NF-kB axis.46 This mechanism may promote activation of the microglial NLRP3 inflammasome and lead to neuroinflammation and neurological manifestations, such as Parkinson's disease.