Stella (also known as DPPA3 or PGC7) protein in oocytes was significantly decreased in HFD-based female mouse, leading to accumulation of maternal 5-hydroxymethylcytosine modifications and DNA lesions, which may be a critical mechanism that mediates the phenotypic effects of maternal obesity in embryos and offspring [8]. Here, DPPA3 is linked to obesity due to melanocortin 4 receptor deficiency.