IL1B and central nervous system cancer: Moreover, under the influence of glioma cells, GAMs become a major source of molecules (e.g., interleukin-1 beta (IL-1β) [13], interleukin-10 (IL-10) [7], vascular endothelial growth factor (VEGF) [14]) that support tumor growth and contribute to an immunosuppressive tumor microenvironment.