According to our knowledge, there has not been any prior research on the variation of the immune (TLR4, TLR7, TNF-α, IL10, NCF4, and LITAF), antioxidant (ATOX1, GST, and OXSR1), and erythritol-related (TKT, RPIA, and AMPD1) markers and how they relate to postparturient endometritis in Holstein dairy cows. The gene discussed is OXSR1; the disease is endometritis.