Data from the present study indicate that exposure to MC-LR gave rise to the up-regulation of the expressions of MKK6, p-p38, p62, TOM20, and LC3-II and the down-regulation of the E3 ubiquitin-protein ligase parkin both in the kidneys of mice and HEK293 cells, which extends the previous studies asserting that mitophagy is a key cellular homeostatic mechanism activated early in acute kidney injury [28,33,53,55,56,57]. The gene discussed is MAP2K6; the disease is acute kidney injury.