Hamilton et al. [164], given the fact that increased IMP expression correlates with enhanced metastasis and poor prognosis in colorectal cancer, observed how IMP1 overexpression modulates tumour dissemination into the blood, promotes colonosphere growth from single tumour cells, and enriches the population of CD24+CD44+ expressing cells, suggesting that IMP1 modulates tumour growth and dissemination of tumour cells into the blood. This evidence concerns the gene CD44 and neoplasm.