Several Nrf2 activators such as resveratrol, sulforaphane, curcumin, and naringenin showed improvements in autistic behavior both in human ASD subjects and mice models of autism which suggests that Nrf2 signaling plays a key role in the amplification of the antioxidant defenses required to protect against oxidant-stress induced by various toxicants/pollutants [27,53,54,55,56]. This evidence concerns the gene NFE2L2 and autism.