For instance, BTBR mice and ASD subjects show upregulation of NF-kB, iNOS, NADPH oxidase, lipid peroxides, and nitrotyrosine which may exacerbate the autism-like symptoms by increasing oxidative damage in the periphery and brain [18,19,27,44,45,46,47,48,49]. This evidence concerns the gene NFKB1 and autism.