The allelic variations of the AT1R gene that result in different receptor isoforms are associated with hypertension and renal tubular dysgenesis, while the allelic variations of the PPARG-γ are linked with severe obesity, type 2 diabetes mellitus and insulin resistance, somatic colon cancer, and type 3 partial familial lipodystrophy. The gene discussed is AGTR1; the disease is type 2 diabetes mellitus.