Interestingly, the six Sartans that only bind to the AT1R (i.e., Valsartan, Olmesartan, Candesartan cilexetil, Eprosartan, Losartan, and Azilsartan medoxomil) have 107 first neighbors and 163 drugs possibly interacting with them, suggesting that they may have fewer side effects due to drug–drug interactions than Paxlovid if they are repurposed against COVID-19 and a higher possibility for side effects that result from off-target interactions than when they are used for the treatment of high blood pressure. This evidence concerns the gene AGTR1 and hypertensive disorder.