The allelic variations of the AT1R gene that result in different receptor isoforms are associated with hypertension and renal tubular dysgenesis, while the allelic variations of the PPARG-γ are linked with severe obesity, type 2 diabetes mellitus and insulin resistance, somatic colon cancer, and type 3 partial familial lipodystrophy. Here, AGTR1 is linked to obesity due to melanocortin 4 receptor deficiency.