In the current study, we aimed to correlate the clinical manifestation of VAS in BC patients, fMRI data, and the serum levels of biomarkers of CNS and endothelial damage, including ICAM-1 (intercellular adhesion molecule 1), PECAM-1 (platelet/endothelial cell adhesion molecule 1), NSE (neuron-specific enolase), and the level of antibodies recognizing NR-2 subunit of NMDA receptor (NR-2-ab). Here, ENO2 is linked to breast cancer.