Herein, in BC patients with vestibulo-atactic syndrome (n = 21), we revealed the correlation between the higher serum levels of ICAM-1, PECAM-1, NSE and the significant changes in the functional connectivity of the brain (according to fMRI data), thus indicating the plausible application of these biomarkers for the evaluation of neuronal and endothelial cell damage in this group of patients. The gene discussed is PECAM1; the disease is breast cancer.