According to the obtained data, we can conclude that metabolic disorders of the LV myocardium caused by insulin-dependent DM as well as in a combination of DM with a hemodynamic hypertensive overload of the LV are accompanied by activation of the mechanisms of both oxidative stress and antioxidant protection, which is evidenced by an enhancement of TXNIP and GS production. Here, TXNIP is linked to metabolic disease.