TP53 and Disorder of lipid metabolism: The genome-wide DNA methylation changes caused by silica nanoparticles in GC-2 cells highlighted the possible influence of silica nanoparticles in male reproductive toxicity [68], and in lipid metabolism disorders and cancer, through p53-mediated apoptotic pathway inhibition in mouse liver and activation of the HRAS-mediated MAPK signaling pathway [95].