As shown in Fig. 11, there was no significant difference in the expression of oncogenes KRAS (Fig. 11A), IDH1 (Fig. 11B) and IDH2 (Fig. 11C), and tumor suppressor gene TP53 (Fig. 11D) between HBV ( +) ICC and HBV (−) ICC. Here, IDH1 is linked to intrahepatic cholangiocarcinoma.