As shown in Fig. 11, there was no significant difference in the expression of oncogenes KRAS (Fig. 11A), IDH1 (Fig. 11B) and IDH2 (Fig. 11C), and tumor suppressor gene TP53 (Fig. 11D) between HBV ( +) ICC and HBV (−) ICC. The gene discussed is IDH2; the disease is intrahepatic cholangiocarcinoma.