The overall incidence of MYC-R in the series was 28% (14/50 cases): 1 HGBCL-NOS, 8 HGBCL with MYC-BLC2/BCL6 R, 4 DLBCL-NOS and 1 BL. The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.