The results of hallmark analysis suggested that many tumor-related signaling pathways were identified for HRPS-group (Figure 3B), such as NF-κB pathway in response to TNF, IL-25 signaling pathway through STAT5, signaling pathway of IL6/JAK/STAT3, p53, KRAS, notch, and TGF-β. This evidence concerns the gene STAT3 and neoplasm.