TRAT1 and central nervous system cancer: Furthermore, TRIM family members and their co-expression genes in gliomas through GO and KEGG pathway analysis were functionally annotated, and these results elucidated the regulation of I-kappaB kinase/NF-kappaB signaling, NIK/NF-kappaB signaling, JAK-STAT cascade, non-canonical Wnt signaling pathway and positive regulation of canonical Wnt signaling pathway in GO as well as NOD-like receptor signaling pathway and NF-kappa B signaling pathway in KEGG.