To study the correlation between TRIM family expression profiles and tumor mutation burden (TMB) and microsatellite instability (MSI) in gliomas, we discovered that TRIM5/21/22/24/28/34/47 were remarkably positively correlated with TMB (P < 0.05), and TRIM17 was significantly negatively correlated with TMB (P < 0.05). Here, TRIM5 is linked to central nervous system cancer.