INS and Insulin resistance: Moreover, we observed no effect of insulin resistance on BCAA media content, which seems at odds with prior observations by our group, which showed a substantial accumulation of extracellular BCAA in insulin-resistant groups [31]; however, an important difference in these experiments is the lack of recovery from excess insulin in the present report, which appears to be necessary for hyperinsulinemic-mediated accumulation of extracellular BCAA.