Furthermore, activation of the lipogenic enzymes, Sterol Regulatory Element-Binding Protein 1 (SREBP-1c) and Carbohydrate Response Element Binding Protein (ChREBP) within the liver in the context of hyperglycaemia and hyperinsulinaemia, contributes toward the worsening of the accumulation of triglycerides within the liver [30]. Here, SREBF1 is linked to Hyperglycemia.