Moreover, treatment with 1,8-Cineol in combination with ellagic acid has been shown to downregulate different cytokines such as transforming growth factor beta-1 (TGF-β1), Fascin-1 (FSCN1), vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in patients with hepatocellular carcinoma (HCC) [62]. This evidence concerns the gene TGFB1 and hepatocellular carcinoma.