ACADVL and pancreatic ductal adenocarcinoma: For example, in the lipid-rich TME region of pancreatic ductal adenocarcinoma, CD8+ T cells decrease the expression of very-long-chain acyl-CoA dehydrogenase (VLCAD) and therefore lead to the accumulation of long-chain fatty acid (LCFA), and ultimately impair mitochondrial function, leading to cell dysfunction [111].