Ding et al. [48] studied human THP-1 cells stimulated by LPS in vitro and DSS-induced C57BL/6J mice model of colitis in vivo to evaluate the effects of evodiamine, a bioactive compound richly found in the fruits of Evodiae fructus, against NLRP3 activation during IBD. This evidence concerns the gene NLRP3 and inflammatory bowel disease.