NLRP3 and inflammatory bowel disease: Zeng et al. [50] studied LPS/ATP-induced RAW264.7 macrophages in vitro and DSS-induced BALB/c mice colitis model in vivo to evaluate the roles of chlorogenic acid, an active dietary polyphenol richly found in honeysuckle, Eucommia and Chaenomeles Lagenaria, against NLRP3 activation during IBD.