Ma et al. [36] studied LPS/ATP-stimulated mouse peritoneal macrophages and BMDMs cells in vitro and DSS-induced C57BL/6 mice colitis model in vivo to evaluate the effects of munronoid I, a diterpenoid richly extracted from the Meliaceae family, against NLRP3 activation during IBD. Here, NLRP3 is linked to inflammatory bowel disease.