To test the effects of the Xianglian Pill, a composition of Coptis chinensis Franch, Evodia rutaecarpa, and Aucklandia lappa Decne, against NLRP3 activation in IBD, Dai et al. [15] studied a DSS-induced C57BL/6 mice model of colitis. Here, NLRP3 is linked to colitis.