Gong et al. [56] studied LPS-primed peritoneal macrophages in vitro and DSS-induced C57BL/6 mice model of colitis in vivo to evaluate the roles of curcumin, a bioactive phenolic compound richly found in Curcuma longa, against NLRP3 activation during these models of IBD. Here, NLRP3 is linked to inflammatory bowel disease.