Phytochemicals such as protopine, moroninc acid, betaine, sanguinarine, hydroxytyrosol, curcumin, dimethyl fumarate, morroniside, 8-oxypalmatine, sinapic acid, and Resveratrol Analog 2-Methoxyl-3,6 Dihydroxyl-IRA contribute to the reduction of ROS, providing additional benefits in the context of NLRP3 activation during IBD. Here, NLRP3 is linked to inflammatory bowel disease.