In their second study, they reported that frail, compared to non-frail patients, were older, less obese, had more prevalent comorbidities, more diabetes-related complications, more frequent hypoglycaemic episodes, less prevalent hyperlipidaemia, less use of hypolipidaemic medications, more insulin and less oral hypoglycaemic agents use [15]. The gene discussed is INS; the disease is hyperlipidemia.