In addition, evidence for involvement of cellular drivers comes from reports that activated monocytes from tumour sites rather than non-tumour tissues more potently induced IL-17A+ CD8+ T-cells in vitro [27] and that pleural mesothelial cells from patients with tuberculosis infection significantly enhanced IL-17 production by patient blood-derived CD8+ T-cells, in a cell–cell contact-dependent manner [11]. This evidence concerns the gene IL17A and neoplasm.