The increase in SK3 channel expression is an unfavorable prognostic marker in renal cancer (The Human Protein Atlas, https://www.proteinatlas.org/ENSG00000143603-KCNN3/pathology, accessed on 27 April 2023), whereas IK channel expression is a poor prognosis marker for urothelial, renal, glioma and pancreatic cancer (https://www.proteinatlas.org/ENSG00000104783-KCNN4/pathology, accessed on 27 April 2023). The gene discussed is KCNN3; the disease is renal carcinoma.