Lastly, worth noting is the fact that ISG15 mRNA expression demonstrated a positive correlation with the day of sepsis development (ISG15–day of sepsis, p = 0.035, rs = 0.42), while it tended to correlate with the day of septic shock development (ISG15–day of septic shock, p = 0.059, rs = 0.39). This evidence concerns the gene ISG15 and Sepsis.