TNF and asthma: Our findings have revealed that obese asthma patients, despite the basic anti-inflammatory therapy, had elevated levels of inflammatory markers in blood plasma such as leptin, tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), IL-4, and IL-17a, leukotriene B4 (LTB4), and thromboxane B2 (TXB2).