Thus, our collective data suggest that RUNX1 acts as an oncogene in PCa by regulating EMT markers, such as E-cadherin, vimentin, slug, snail, and twist1, as well as MMP2 and MMP9, via the activation of the Akt/JNK and P38 MAPK signaling pathways. This evidence concerns the gene SNAI1 and posterior cortical atrophy.