PIK3CD and urinary bladder cancer: Considering sea cucumbers, prior studies demonstrated that the triterpene glycoside frondoside A from Cucumaria frondosa could inhibit the migration of a human bladder cancer cell line (UM-UC-3) [45] and the MDA-MB-231 breast cancer cell line via the downregulation of the P38/MAPK and PI3K/Akt pathways [45].