As a consequence of the impairment of the RUNX1 translocation, the process of EMT was inhibited by the upregulating expression of E-cadherin, and the downregulating expression of vimentin, twist1, slug, and snail, thus preventing the metastasis of PCa cell lines via decreasing MMP2 and MMP9 protein expressions. This evidence concerns the gene MMP2 and posterior cortical atrophy.