CASP3 and neoplasm: As shown in our results, Chr-A treatment stimulated the apoptosis heightening ratio of Bax/Bcl-2 and activated caspases, including caspase 3, caspase 7 and caspase 9 of glioblastoma cells in vivo and in vitro, thus confirming the enrichment analysis that Chr-A leads to tumor regression via apoptosis-promoting.