PPIB and fungal infectious disease: Classically, the β-D-glucan assay is a serodiagnostic method for invasive fungal infections such as aspergillosis and candidiasis [45]; however, if the profiling of β-D-glucan can potentially detect 82% of talaromycosis cases, it is likely that the β-D-glucan assay may be a viable candidate for the clinical diagnosis of T. marneffei-infected patients in non-endemic regions who have a history of travel to endemic regions.