Interestingly, the CD11b+/moDCs were shown to infiltrate to the lungs during cryptococcal infection via trafficking by CCR2, and in CCR2-deficient mice, cryptococcal infection led to a shift to Th2 type responses, including increased collagen deposition and increased IL-4, indicating a non-protective immune response [74]. The gene discussed is ITGAM; the disease is cryptococcosis.