MT-CYB and reproductive system disorder: As suggested by the literature, downregulation of cox and cytb genes in testes, which control energy metabolism, can be associated with testicular atrophy [65], while upregulation of cox genes can produce proinflammatory cytokines and reactive oxygen species which are responsible for the development of several types of cancers [66], illustrating that adult Δ9-THC exposure might have developed oxidative stress in medaka testis, which may lead to several reproductive diseases.