BMP2 and craniosynostosis: Furthermore, DIPY has been proven to stimulate bone regeneration to levels comparable to that of growth factors such as Bone Morphogenetic Protein 2 (BMP-2), one of the most studied osteogenic agents for bone regeneration, without the associated side effects, such as ectopic bone formation, osteolysis, and craniosynostosis [36,41,42,43].