Fabry disease (FD, OMIM 301500) is an X-linked lysosomal disorder, caused by α-galactosidase A (α-GalA) deficiency, encoded by GLA gene, that leads to progressive accumulation of globotriaosylceramide (Gb3) and related glycosphingolipids (Figure 1) [1,2]. This evidence concerns the gene GLA and Fabry disease.