JAK2 and essential thrombocythemia: In this report, we describe two MPN patients with simultaneous double <i>MPL</i> mutations: a woman with ET presenting both <i>MPL</i><sup>V501A-W515R</sup> and <i>JAK2</i><sup>V617F</sup> mutations and a man with PMF displaying an uncommon double <i>MPL</i><sup>V501A-W515L</sup>.