OS biomarkers MDA, FRAP, protein carbonyls, and peroxynitrite, and inflammation biomarkers ILC2/3, MMP-12, CXCL8, neutrophil elastase, AZU-1, and PPBP were found to associate with asthma in smokers, but not in nonsmokers. The gene discussed is CXCL8; the disease is asthma.