Moreover, Zhou et al. (2012) revealed that PCa progression is positively correlated with the expression level of the enzyme that catalyzes the remodeling of phosphatidylcholine (PC) reaction, namely lysophosphatidylcholine acyltransferase 1 (LPCAT1), and this correlation was independent of age, race and PSA levels of PCa patients, proposing LPCAT1 and LPC as novel biomarkers for PCa detection [28]. The gene discussed is KLK3; the disease is posterior cortical atrophy.