Liver and hepatoma cells renowned for their low nSMase2 content [9,10,11,12,13,14,15,16] and Figure 3 differ, as high BSO concentrations translated in extremely low glutathione content and tremendous increase in ROS accumulation led to a remarkable increase in HepG2 cell proliferative potential [46,47,48] and Figure 6. The gene discussed is SMPD3; the disease is hepatocellular carcinoma.