Consistent with this, A2AR activation alleviates symptoms of inflammatory diseases, such as multiple sclerosis (MS) [30], rheumatoid arthritis (RA) [31], acute lung injury (ALI) [32], ischemia-reperfusion injury (IRI) of the kidney [33,34], and inflammatory bowel disease (IBD) [35]. Here, ADORA2A is linked to inflammatory bowel disease.