Cholesterol export requires NPC intracellular cholesterol transporter 1 (NPC1) and NPC2, genetic mutations of which can cause Niemann–Pick type C (NPC) disease, a disorder characterized by massive lysosomal accumulation of cholesterol and glycosphingolipids [38] NPC disease affects various organs and systems in the body, including the liver, spleen, and brain, leading to a range of symptoms that can include hepatosplenomegaly, progressive neurological deterioration, and cognitive decline. This evidence concerns the gene NPC1 and Mental deterioration.