INS and obesity due to melanocortin 4 receptor deficiency: For example, ellagic acid inhibits adipogenesis by suppressing the terminal differentiation and lipid accumulation in 3T3-L1 adipocytes [63]; gallic acid increases insulin sensitivity and reduces obesity [36]; chebulinic acid acts as a potent antiadipogenic agent suppressing the differentiation of 3T3-L1 preadipocytes into mature adipocytes [43]; and 6-gingerol inhibits adipogenesis in 3T3-L1 cells [64].