In this study, besides supporting the use of the TPDM6315 recipe for anti-fever and determining its potential anti-obesity effects by investigating the anti-inflammatory activity in its macrophages and reducing the lipid accumulation in its adipocytes, it was interesting to explore the anti-inflammatory effects of TPDM6315 on TNF-α-induced adipocytes, in order to evaluate the possibility of a novel use of this recipe for the treatment of metabolic diseases such as insulin resistance. This evidence concerns the gene TNF and metabolic disease.