While Pmm1 was significantly upregulated in all three PAH models (by 11.87x in HO, 17.71x in CM, and 26.04x in HM), Pmm2 was significantly downregulated in all three (by −4.65x in HO, −3.50x in CM, and −3.14x in HM). The gene discussed is PMM1; the disease is pulmonary arterial hypertension.