Another surprising finding was the switch from 46.2% synergistic partners and 0% antagonistic ones for Aldh3a1 in CO, to 0% synergism and 51.3% antagonism in CM, although in the other two PAH models, it was only synergistically connected; in all three models it was significantly downregulated. This evidence concerns the gene ALDH3A1 and pulmonary arterial hypertension.