In addition to this, several recent studies have found that the majority of ALK-rearranged RCC cases showed positive results for biomarkers such as PAX7, CK10, AMACR, CD3, and cytokeratin; negative results for biomarkers such as carbonic anhydrase IX, TFE45, histone enzyme K, Melan A, and HMB45 [70,71]. This evidence concerns the gene PMEL and renal cell carcinoma.