MALAT1 and cancer: PRC2 is, however, one of the most studied MALAT1 partners in tumors [19]: first, RNA immunoprecipitation (RIP) experiments performed on cancer cell extracts show that both molecules are part of a complex in the nucleoplasm [20,21,22]; second, genes such as PCDH10 and E-cadherin are derepressed in cancer cells following MALAT1 or PRC2 down-regulation [21,22,23].