Since the discovery of MALAT1 in lung cancer cells [12], the epigenetic complex PRC2 has been proposed as a key regulatory partner [19], particularly after loss-of-function studies that measure the effect on specific target genes, where an independent knock-down of MALAT1 or of some of the PRC2 subunits results in gene de-repression [21,22,23]. Here, MALAT1 is linked to lung carcinoma.