MBD2 and metastatic malignant neoplasm in the lymph nodes: To better understand the epigenetic control of cell invasion and metastasis in HNSCC, in the present study, we examined the expression profile of DNA methyltransferases/demethylases in tumors with perineural invasion (PNI), perivascular invasion (PVI), and/or lymphovascular invasion (LVI) and in tumors with regional lymph node metastases (pN+).