To further our knowledge of the regulation of CpG73 methylation, the present study correlated the level of CpG73 methylation with the expression profile of DNMT1, DNMT3A, DNMT3B, TET1, TET2, TET3, TDG, and TRDM1 in tumor and normal tissues. The gene discussed is DNMT3A; the disease is neoplasm.