DNMT1 and neoplasm: On the contrary, the expression of DNMT1, 3A, and 3B did not differ between tumor and paired normal tissue in pN+ tumors and was diminished in comparison to non-metastatic (pN0) tumors (DNMT1 and 3A: Sidak’s multiple comparisons test, p < 0.001; DNMT3B: Sidak’s multiple comparisons test, p < 0.05) (Figure 1A–C).