We determined the expression profile of the DNA methyltransferases DNMT1, DNMT3A, and DNMT3B, the DNA demethylases TET1, TET2, and TET3, and the RNA methyltransferase TRDMT1 in HNSCC tumors driven by HPV16. This evidence concerns the gene TRDMT1 and head and neck squamous cell carcinoma.